What is Non-Muscle Invasive Bladder Cancer (NMIBC)?

These muscles are protected from the center of the bladder, as they are positioned underneath the bladder lining and layers of tissue.

Non-muscle invasive bladder cancer (NMIBC) happens when cancer cells grow in this tissue area that lines the center of the bladder, but the cancer does not reach any layers of bladder muscle.

Usually, the first step in treating bladder cancer involves surgery through a bladder scope to remove the tumor, followed by bacillus Calmett-Guerin therapy to reduce the risk of the cancer coming back. BCG therapy does not work for everyone, and some have trouble handling it.  Some patients might also choose other treatments instead of BCG. If the cancer comes back, bladder removal is often recommended. The LEGEND study is designed to find out if the study drug could be a safe and effective option for patients that would hopefully treat the cancer cells, prevent them from coming back and delay or avoid the removal of their bladder.